In Orthodox Jewish circles, where terminating the birth would be undesirable, a mate selection program has been in place. The organization Dor Yeshorim or Committee for Prevention of Genetic Diseases offers and encourages genetic screening for the Jewish community across the world. Using an anonymous system of PIN numbers, they test for multiple autosomal recessive disorders, not only Tay-Sachs. When two potential partners wish to have a child or get married, they enter their PIN numbers and the system will inform them if they both carry a recessive gene, thus discouraging the match.
While this may indicate and more extreme implementation of eugenics today, it is difficult to deny that their program has not yielded positive results. Through modern science and an anonymous testing process, Dor Yeshorim has been successful in preventing further births with such debilitating diseases such as Tay-Sachs, albiet only in the Jewish community which chooses to participate. However, it does bring up yet more ethical questions, such as the desirability of arranged marriages based on genetic factors. Not only this, but this could be interpreted as a specific and unique scenario- the genetic mutation responsible for Tay-Sachs is distinctly more prevalent in a certain population, not to mention a population that is more open to the concept of arranging marriages based on fitness; if such a program could be implemented on a larger scale with respect to other diseases is yet to be known.
Here are some links about Dor Yoreshim, their program, and the Jewish initiative to wipe out Tay-Sachs: